Good pubs near Chinatown Den. For range of beers I'd suggest the City Arms, which is near the Town Hall. At the top of king Street, you have Reform, which is a cocktail bar/restaurant, but does half price drinks up 'til 7pm (I think) and is worth a visit for the fantastic decor. On Cross Street you've got the Chop House, and as Colin says, bang in the middle of Chinatown there is the Sevenoaks, which I'd avoid if there's a few of you. The Old Monkey is a boozers pub, and the Waterhouse is spacious and, of course, cheap.
As for Cloud 23 I took my son in for his 21st last night. It's tacky and expensive - very Manc you might say! The view is southwards, rather than across the city centre. Worth a visit though. You'll probably have to queue to get in.
My favourite in Manchester is the Mark Addy. Brilliant food at realworld prices.